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Advil® is the #1 selling pain reliever,* providing safe, effective pain relief for over 30 years. Diffen The effect of an Advil pill lasts for 4 to 8 hrs while that of Aleve lasts for 8 to 12 hrs. Naproxen may interact with antidepressants, lithium, methotrexate, probenecid, warfarin and other blood thinners, heart or blood pressure medications, including diuretics, or steroid medicines such as prednisone Make pain a distant memory. Aleve's 40-count gelcap SKU is still being. In. Find patient medical information for Aleve PM Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings For the first dose, you can take two Aleve within the first hour. Now I know it was the Aleve. 87,334 Discussions. Skip to end of links $ 14. 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